C KOUAM KOUAM, V L. NZEUSSEU, J-DE-D TAMOKOU, J R. KUIATE.

 Background: high blood pressure is a major risk factor of stroke, coronary heart disease, cardiac and renal failure who are the leading causes of death worldwide.    For a better understanding of some biological changing occurring in persons developing high blood pressure  ,  we decided  to  evaluate  the  prevalence  of  some  biochemical  abnormalities  in   hypertensive patients at the Bafoussam Regional Hospital .

Methods: the study population consisted of 63 hypertensive patients (mean age 59,4 years)  naïve of any blood lowering treatment and 125 non-hypertensive control subjects.  Enrollment took place at the first trimester of the year 2015.  Biochemical  parameters  considered  were  total-cholesterol,  HDL-cholesterol ,  LDL-cholesterol , triglycerides ,  serum creatinine, serum  albumin and serum  potassium  .    Urine protein, glucose and red blood cell presence were notice. The glomerular filtration rate (GFR) was estimated for each participant.

Results:  Hypertensive patients were more likely to be active smoking, to drink alcohol and have low level of physical exercise    (p<0.05).   Hypertensive  patients had significant  decrease  of  GFR,  significant  increase  of  haematuria,  body  mass  index  ,  total-cholesterol,  HDL  cholesterol, LDL  cholesterol , serum potassium,  serum creatinine ,  proteinuria  and  glycosuria . 

Conclusion: We find major biochemicals changes in the newly diagnosed hypertensive patients suggestive of organ damage with high likelihood of fatal outcome in the future.

Keywords:  High blood pressure, risk factors, biochemical markers, Bafoussam, organ damage.