Get Adobe Flash player
1525981
Today
Total :
2107
1525981

P1. THE SHORT-TERM EFFECT OF A VERY LOW CALORIE DIET ON THE AMBULATORY BLOOD PRESSURE PROFILE IN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS

Daniel N. Ndipenock1, Jean Claude Mbanya1,2,3, Eugene Sobngwi1,2,3, Francois F. Kaze1,4, Mesmin Dehayem1,2,3, Merveille A. Musi1, Raissa NC Abomo1, Crista T. Arrey3

 

Authors’ affiliations

  1. Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I
  2. Endocrine and Metabolic Diseases Unit, Yaoundé Central Hospital, Yaoundé, Cameroon
  3. National Obesity Center, Yaoundé, Cameroon
  4. Internal Medicine Unit, University Teaching Hospital, Yaoundé, Cameroon

 

Corresponding author: Eugene Sobngwi. E-mail: Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.

 

Abstract

Aim: To determine the effect of an 8-week daily very low calorie diet on the ambulatory blood pressure profile in patients with newly diagnosed type 2 diabetes mellitus.

Methods: We undertook a non-randomized single-arm clinical trial over a period of 6 months in patients with newly diagnosed type 2 diabetes, naïve to anti-diabetic medications, with HbA1c between 47.5 – 80.3mmol/mol (6.5 – 9.5%), body mass index greater than 25kg/m2. The intervention daily consumption of foods containing 600 kcal of energy over a period of eight weeks. Before and after intervention, we assessed: weight, body composition, resting and exercise-induced urinary albumin excretion (UAE), 24-hour blood pressure profile, glycated hemoglobin, fasting blood glucose, and serum lipid profile (Triglycerides, Total cholesterol, HDL cholesterol, LDL cholesterol).

Result: We included 18 participants, (10 females, 8 males), aged 53 [45-57] years. We noted the following percentage reductions: 1.1% BMI (p < 0.001), 10.7% fat mass (p<0.001), 46.2% FBG (p<0.001), 14.7% HbA1c (p<0.001), 14.3% triglycerides (p=0.028), 74% resting UAE (p=0.37), 67.9% exercise-induced UAE (p=0.22). The following changes were noted for ABPM parameters: 2.3% reduction in 24h SBP(p=0.88), 5.2% reduction in 24h DBP (p=0.55), 2.6% reduction in daytime SBP (p=0.65), 3.2% reduction in daytime DBP (p=0.65), 1.0% reduction in nighttime SBP (p=0.52), 1.8% increase in nighttime DBP (p=0.59), 4.9% reduction in MAP (p=0.93).

Conclusion: In patients with type 2 diabetes mellitus within one year of diagnosis, the therapeutic use of an 8-week-600-kilocalorie daily diet does not significantly reduce the ambulatory blood pressure profile in the short run.

 

Keywords: Very low calorie diet, type 2 diabetes, ambulatory blood pressure profile